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Breakthrough Therapy designation complements Rusfertide’s Orphan Drug and Fast Track designations, which together confer multiple benefits to the development program

U.S. New Drug Application filing for Rusfertide in polycythemia vera on track for Q4

NEWARK, CA / ACCESS Newswire / August 25, 2025 / Protagonist Therapeutics, Inc. (“Protagonist” or “the Company”) announced today that rusfertide, a potential first-in-class hepcidin-mimetic peptide, has been granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of erythrocytosis in patients with polycythemia vera (PV). In 2020, rusfertide received Orphan Drug status and Fast Track designation. Breakthrough Therapy Designation is a process designed to expedite the development and review of drugs that are intended to treat a serious condition and preliminary clinical evidence indicates that the drug may demonstrate substantial improvement over available therapies.¹ Breakthrough Therapy Designation also conveys eligibility for priority NDA review¹ and Orphan Drug Designation qualifies sponsors for various incentives including a potential for extended market exclusivity.²

Breakthrough designation for rusfertide was supported by positive 32-week data from the Phase 3 VERIFY study, which was presented as a late breaking abstract highlighting its practice-changing potential during the plenary session at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting.

“We are very pleased with the FDA’s decision to grant Breakthrough Therapy Designation to rusfertide, which underscores its potential to demonstrate substantial improvement over available PV therapies,” said Dinesh V. Patel, Ph.D., President and Chief Executive Officer at Protagonist. We remain on track for NDA submission of rusfertide in polycythemia vera by the end of this year.”

“In the VERIFY Phase 3 trial, rusfertide demonstrated positive results across all primary and key secondary endpoints including hematocrit control, decreased phlebotomy dependence, and patient reported outcomes including improvement in fatigue,” said Arturo Molina, M.D., M.S., Chief Medical Officer at Protagonist. “The comprehensive data provide compelling evidence of the potential for rusfertide to address unmet medical needs in patients with PV who are unable to achieve adequate hematocrit control with standard of care or currently available treatments.”

Rusfertide is being co-developed with Takeda Pharmaceuticals pursuant to a worldwide collaboration and license agreement entered in 2024, under which Protagonist remains primarily responsible for development through NDA filing.

About VERIFY
The Phase 3 VERIFY study (NCT05210790) is an ongoing, three-part, global, randomized, placebo-controlled study evaluating rusfertide in 293 patients with polycythemia vera over a 156-week period. The study is evaluating the efficacy and safety of once-weekly, subcutaneously self-administered rusfertide in patients with uncontrolled hematocrit who are phlebotomy dependent despite current standard of care treatment, which could include hydroxyurea, interferon and/or ruxolitinib. The primary endpoint of the study was the proportion of patients achieving a response during weeks 20-32, which was defined as the absence of “phlebotomy eligibility.” To meet phlebotomy eligibility, patients in the study were required to have: confirmed hematocrit ≥45% that was ≥3% higher than their baseline hematocrit value, or hematocrit ≥48%.

All patients have completed their participation in the randomized, placebo-controlled portion of the study evaluating the efficacy and safety of rusfertide plus current treatment versus placebo plus current treatment and are now in the open-label portion of the study.

About Protagonist
Protagonist Therapeutics is a discovery through late-stage development biopharmaceutical company. Two novel peptides derived from Protagonist’s proprietary discovery platform are currently in advanced Phase 3 clinical development, with New Drug Application (NDA) for icotrokinra submitted to the FDA in July and the NDA submission for rusfertide expected by end of 2025. Icotrokinra (formerly, JNJ-2113), a first-in-class investigational targeted oral peptide that selectively blocks the Interleukin-23 receptor (“IL-23R”) is licensed to J&J Innovative Medicines (“JNJ”), formerly Janssen Biotech, Inc.. Following icotrokinra’s joint discovery by Protagonist and JNJ scientists pursuant to the companies’ IL-23R collaboration, Protagonist was primarily responsible for development of icotrokinra through Phase 1, with JNJ assuming responsibility for development in Phase 2 and beyond. Rusfertide, a mimetic of the natural hormone hepcidin, is currently in Phase 3 development for the rare blood disorder polycythemia vera (PV). Rusfertide is being co-developed and will be co-commercialized with Takeda Pharmaceuticals pursuant to a worldwide collaboration and license agreement entered in 2024 under which the Company remains primarily responsible for development through NDA filing. The Company also has a number of pre-clinical stage drug discovery programs addressing clinically and commercially validated targets, including IL-17 oral peptide antagonist PN-881, an obesity triple agonist peptide PN-477, and the oral hepcidin program.

More information on Protagonist, its pipeline drug candidates and clinical studies can be found on the Company’s website at https://www.protagonist-inc.com/.

Cautionary Note on Forward-Looking Statements
This press release contains forward-looking statements for purposes of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Forward-looking statements include statements regarding the potential benefits of rusfertide and the timing of rusfertide regulatory submissions. In some cases, you can identify these statements by forward-looking words such as “anticipate,” “believe,” “may,” “will,” “expect,” or the negative or plural of these words or similar expressions. Forward-looking statements are not guarantees of future performance and are subject to risks and uncertainties that could cause actual results and events to differ materially from those anticipated, including, but not limited to, our ability to develop and commercialize our product candidates, our ability to earn milestone payments under our collaboration agreements with Janssen and Takeda, our ability to use and expand our programs to build a pipeline of product candidates, our ability to obtain and maintain regulatory approval of our product candidates, our ability to operate in a competitive industry and compete successfully against competitors that have greater resources than we do, and our ability to obtain and adequately protect intellectual property rights for our product candidates. Additional information concerning these and other risk factors affecting our business can be found in our periodic filings with the Securities and Exchange Commission, including under the heading “Risk Factors” contained in our most recently filed periodic reports on Form 10-K and Form 10-Q filed with the Securities and Exchange Commission. Forward-looking statements are not guarantees of future performance, and our actual results of operations, financial condition and liquidity, and the development of the industry in which we operate, may differ materially from the forward-looking statements contained in this press release. Any forward-looking statements that we make in this press release speak only as of the date of this press release. We assume no obligation to update our forward-looking statements, whether as a result of new information, future events or otherwise, after the date of this press release.

Investor Relations Contact
Corey Davis, Ph.D.
LifeSci Advisors
cdavis@lifesciadvisors.com
+1 212 915 2577

Media Relations Contact
Virginia Amann
ENTENTE Network of Companies
virginiaamann@ententeinc.com
+1 833 500 0061 ext 1

Endnotes

View the original press release on ACCESS Newswire

LONDON, UK AND VANCOUVER, BC / ACCESS Newswire / August 25, 2025 / CoTec Holdings Corp. (TSXV:CTH)(OTCQB:CTHCF) (“CoTec”) and Mkango Resources Ltd. (AIM/TSX-V: MKA) (“Mkango”) are pleased to announce that Intelligent Lifecycle Solutions LLC (“ILS”) has formally commenced its stockpiling of feedstock initiative pursuant to the recently announced feedstock supply and pre-processing site share agreement between HyProMag USA LLC (“HyProMag USA” or the “Project”) and ILS. Pre-processing of the feedstock is expected to commence prior to December 31, 2025.

The stockpiling and pre-processing will take place at both the ILS sites in Williston, South Carolina and Reno, Nevada (the “ILS sites”). ILS is a global electronics recycling company processing electronic waste. It is a full-service IT asset disposition, electronics recycling and scrap purchasing company and is fully compliant in ISO 14001:2015, ISO 45001:2018 and “Responsible Recycling R2v3 Recycler” at its USA locations. Through ILS, HyProMag USA will provide full traceability on its products to support the “closed loop” circular economy and critical mineral supply chains within the United States.

Julian Treger, CoTec CEO commented:“This is another major milestone in the execution of the HyProMag USA project. Securing feedstock is key to the success of any recycling business and we are pleased to work with credible companies such as ILS. HyProMag USA’s target is to secure between 6 months and 12 months of feedstock prior to commissioning of HyProMag USA’s advanced stage rare earth magnet recycling and manufacturing plant to be located in Dallas-Fort Worth, Texas. HyProMag USA aims to become a major contributor to the USA supply chain of rare earth magnets, a critical input for accelerating the reshoring of the U.S industrial base.”

Will Dawes, Mkango CEO commented: “The agreement with ILS and commencement of stockpiling of NdFeB feedstock underpins the rapid deployment of Hydrogen Processing of Magnet Scrap (HPMS) and associated magnet manufacturing into the United States by HyProMag USA, with detailed engineering well underway following the positive feasibility study last year. These developments will catalyse development of a more robust rare earth supply chain, whilst unlocking new NdFeB scrap sources in the United States and generating significant value for HyProMag USA and its stakeholders.”

About HyProMag USA LLC.

HyProMag USA is owned 50:50 by CoTec and HyProMag Limited. HyProMag Limited is 100 per cent owned by Maginito (“Maginito”), which is owned on a 79.4/20.6 per cent basis by Mkango and CoTec.

For more information, please visit www.hypromagusa.com

About CoTec Holdings Corp.

CoTec is a publicly traded investment issuer listed on the Toronto Venture Stock Exchange (“TSX- V”) and the OTCQB and trades under the symbols CTH and CTHCF respectively. CoTec Holdings Corp. is a forward-thinking resource extraction company committed to revolutionizing the global metals and minerals industry through innovative, environmentally sustainable technologies and strategic asset acquisitions. With a mission to drive the sector toward a low-carbon future, CoTec employs a dual approach: investing in disruptive mineral extraction technologies that enhance efficiency and sustainability while applying these technologies to undervalued mining assets to unlock their full potential. By focusing on recycling, waste mining, and scalable solutions, the Company accelerates the production of critical minerals, shortens development timelines, and reduces environmental impact. CoTec’s strategic model delivers low capital requirements, rapid revenue generation, and high barriers to entry, positioning it as a leading mid-tier disruptor in the commodities sector.

For more information, please visit www.cotec.ca.

About Mkango Resources Ltd.

Mkango is listed on the AIM and the TSX-V. Mkango’s corporate strategy is to become a market leader in the production of recycled rare earth magnets, alloys and oxides, through its interest in Maginito Limited (“Maginito”), which is owned 79.4 per cent by Mkango and 20.6 per cent by CoTec, and to develop new sustainable sources of neodymium, praseodymium, dysprosium and terbium to supply accelerating demand from electric vehicles, wind turbines and other clean energy technologies.

Maginito holds a 100 per cent interest in HyProMag and a 90 per cent direct and indirect interest (assuming conversion of Maginito’s convertible loan) in HyProMag GmbH, focused on short loop rare earth magnet recycling in the UK and Germany, respectively, and a 100 per cent interest in Mkango Rare Earths UK Ltd (“Mkango UK”), focused on long loop rare earth magnet recycling in the UK via a chemical route.

Maginito and CoTec are also rolling out HPMS recycling technology into the United States via the 50/50 owned HyProMag USA LLC joint venture company.

Mkango also owns the advanced stage Songwe Hill rare earths project in Malawi (“Songwe”) and the Pulawy rare earths separation project in Poland (“Pulawy”). Both the Songwe and Pulawy projects have been selected as Strategic Projects under the European Union Critical Raw Materials Act. Mkango has signed a Binding Combination Agreement with Crown PropTech Acquisitions to list the Songwe Hill and Pulawy rare earths projects on NASDAQ via a SPAC Merger.

For more information, please visit www.mkango.ca

Market Abuse Regulation (MAR) Disclosure

The information contained within this announcement is deemed by the Company to constitute inside information as stipulated under the Market Abuse Regulations (EU) No. 596/2014 (‘MAR’) which has been incorporated into UK law by the European Union (Withdrawal) Act 2018. Upon the publication of this announcement via Regulatory Information Service, this inside information is now considered to be in the public domain.

Cautionary Note Regarding Forward-Looking Statements

This news release contains forward-looking statements (within the meaning of that term under applicable securities laws) with respect to Mkango and CoTec. Generally, forward looking statements can be identified by the use of words such as “plans”, “expects” or “is expected to”, “scheduled”, “estimates” “intends”, “anticipates”, “believes”, or variations of such words and phrases, or statements that certain actions, events or results “can”, “may”, “could”, “would”, “should”, “might” or “will”, occur or be achieved, or the negative connotations thereof. Readers are cautioned not to place undue reliance on forward-looking statements, as there can be no assurance that the plans, intentions or expectations upon which they are based will occur. By their nature, forward-looking statements involve numerous assumptions, known and unknown risks and uncertainties, both general and specific, that contribute to the possibility that the predictions, forecasts, projections and other forward-looking statements will not occur, which may cause actual performance and results in future periods to differ materially from any estimates or projections of future performance or results expressed or implied by such forward-looking statements. Such factors and risks include, without limiting the foregoing, the delivery and effectiveness of the HDD magnet separation system built by Inserma, the results of the Accelerated Pilot Programme at UoB, the availability of (or delays in obtaining) financing to develop Songwe Hill, the Recycling Plants being developed by Maginito in the UK, Germany and the US (the “Maginito Recycling Plants”), governmental action and other market effects on global demand and pricing for the metals and associated downstream products for which Mkango is exploring, researching and developing, geological, technical and regulatory matters relating to the development of Songwe Hill, the ability to scale the HPMS and chemical recycling technologies to commercial scale, competitors having greater financial capability and effective competing technologies in the recycling and separation business of Maginito and Mkango, availability of scrap supplies for Maginito’s recycling activities, government regulation (including the impact of environmental and other regulations) on and the economics in relation to recycling and the development of the Maginito Recycling Plants, and Pulawy and future investments in the United States pursuant to the proposed cooperation agreement between Maginito and CoTec, cost overruns, complexities in building and operating the plants, and the positive results of feasibility studies on the various proposed aspects of Mkango’s, Maginito’s and CoTec’s activities. The forward-looking statements contained in this news release are made as of the date of this news release. Except as required by law, the Company and CoTec disclaim any intention and assume no obligation to update or revise any forward-looking statements, whether because of new information, future events or otherwise, except as required by applicable law. Additionally, the Company and CoTec undertake no obligation to comment on the expectations of, or statements made by, third parties in respect of the matters discussed above.

For further information on CoTec, please contact:

CoTec Holdings Corp.
Braam Jonker
Chief Financial Officer
braam.jonker@cotec.ca
Canada: +1 604 992-5600

For further information on Mkango, please contact:

SP Angel Corporate Finance LLP
Nominated Adviser and Joint Broker
Jeff Keating, Jen Clarke, Devik Mehta
UK: +44 20 3470 0470

Alternative Resource Capital
Joint Broker
Alex Wood, Keith Dowsing
UK: +44 20 7186 9004/5

The TSX Venture Exchange has neither approved nor disapproved the contents of this press release. Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

This press release does not constitute an offer to sell or a solicitation of an offer to buy any equity or other securities of the Company in the United States. The securities of the Company will not be registered under the United States Securities Act of 1933, as amended (the “U.S. Securities Act”) and may not be offered or sold within the United States to, or for the account or benefit of, U.S. persons except in certain transactions exempt from the registration requirements of the U.S. Securities Act.

SOURCE: CoTec Holdings Corp.

View the original press release on ACCESS Newswire

Company remains on path to compliance following progress on strategic initiatives

MIAMI, FLORIDA / ACCESS Newswire / August 25, 2025 / Safe & Green Holdings Corp. (Nasdaq:SGBX) (“Safe & Green” or the “Company”), a leading developer of sustainable solutions and modular infrastructure, today announced that it has received notice from The Nasdaq Stock Market LLC (“Nasdaq”) granting the Company an extension to regain compliance with Nasdaq’s continued listing requirements.

The Nasdaq Hearings Panel acknowledged the significant progress Safe & Green has made toward completing its previously announced reverse stock split and granted the Company additional time to finalize the process. Under the terms of the extension, Safe & Green must complete the reverse stock split and demonstrate a minimum bid price of at least $1.00 per share for ten consecutive trading sessions by September 22, 2025.

“We are pleased that Nasdaq has recognized the progress we have made and granted us additional time to complete the reverse stock split,” said Mike Mclaren, CEO of Safe & Green Holdings. “We remain confident in our ability to meet these requirements and to continue executing on our long-term growth strategy. This extension ensures we can maintain our Nasdaq listing, which is important to our investors and our business as we move forward.”

Safe & Green has already met prior milestones established by Nasdaq and continues to take steps to ensure full compliance with all listing requirements.

About Safe & Green Holdings
Safe & Green Holdings Corp. is a leading provider of modular construction and sustainable infrastructure solutions, serving customers across multiple industries including healthcare, education, energy, and government. The Company’s subsidiaries focus on delivering innovative, cost-efficient, and environmentally conscious solutions that drive long-term value creation.

Safe Harbor Statement

Certain statements in this press release constitute “forward-looking statements” within the meaning of the federal securities laws. Words such as “may,” “might,” “will,” “should,” “believe,” “expect,” “anticipate,” “estimate,” “continue,” “predict,” “forecast,” “project,” “plan,” “intend” or similar expressions, or statements regarding intent, belief, or current expectations, are forward-looking statements. These forward-looking statements are based upon current estimates and assumptions. While the Company believes these forward-looking statements are reasonable, undue reliance should not be placed on any such forward-looking statements, which are based on information available to us on the date of this release. These forward-looking statements are subject to various risks and uncertainties, many of which are difficult to predict that could cause actual results to differ materially from current expectations and assumptions from those set forth or implied by any forward-looking statements. Important factors that could cause actual results to differ materially from current expectations include, among others, the Company’s ability to maintain compliance with the NASDAQ listing requirements, and the other factors discussed in the Company’s Annual Report on Form 10-K for the year ended December 31, 2024 and its subsequent filings with the SEC, including subsequent periodic reports on Forms 10-Q and 8-K. The information in this release is provided only as of the date of this release, and we undertake no obligation to update any forward-looking statements contained in this release on account of new information, future events, or otherwise, except as required by law.

Investor Contact

Investors@safeandgreenholdings.com

SOURCE: Safe & Green Holdings Corp

View the original press release on ACCESS Newswire

VANCOUVER, BC / ACCESS Newswire / August 25, 2025 / Avino Silver & Gold Mines Ltd. (TSX:ASM)(NYSE American:ASM)(FSE:GV6) (“Avino” or the “Company”), a long-standing silver producer in Mexico, is pleased to announce that the Company has acquired 100% ownership of its La Preciosa project (“La Preciosa“) by purchasing and extinguishing all of the outstanding royalties and contingent payment obligations (the “La Preciosa Obligations“), currently held by Deterra Royalties Limited (DRR) (“Deterra“) (collectively, the “Transaction“). The consideration for this royalty purchase is a $13.25 million upfront payment followed by an $8.75 million payment deferred for one year. This second payment was already accounted for in the existing royalty agreement with Deterra.

Highlights of this transaction:

• Restores full value and control of La Preciosa

• Optimizes financial structure

• Enhances project economics

• Reduces administrative burdens

• Manageable impact on financial liquidity

“Avino has seized upon a unique opportunity to buy back all the royalties on La Preciosa” said David Wolfin, President and CEO. “This cornerstone asset is now materially unencumbered, and this transaction represents a unique investment opportunity for Avino, as operators rarely get the chance to increase project value through the purchase of previously-granted royalties. By eliminating the royalty burden immediately prior to commencing production, we believe we will generate meaningful returns on our investment by lowering La Preciosa’s operating cost profile, and ensuring that as much of La Preciosa’s value remains with the operator and its stakeholders. The incremental cash outlay of only US$13.25 million represents an acquisition that is accretive to Avino shareholders on a net asset value (NAV) per share basis. The current metal price environment has enabled Avino to generate significant profits and cash flows from its current Avino mine operations, leading to the strongest balance sheet in the Company’s history and granting the ability to pursue investment opportunities that enhance shareholder value such as this. I would like to thank Deterra for being great partners as our team continued to advance La Preciosa on its way to production and I am thrilled to have reached an agreement where it was a win for both parties.”

The La Preciosa Obligations are comprised of:

1. a cash payment of US$8.75 million, to be paid no later than 12 months after initial production at La Preciosa (the “Contingent Production Payment“);

2. a 1.25% net smelter returns royalty on the Gloria and Abundancia areas of La Preciosa, and a 2.00% gross value returns royalty on all other areas of La Preciosa; and

3. a payment of US$0.25 per silver equivalent ounce (subject to inflationary adjustment) of new mineral reserves (as defined by NI 43-101) discovered and declared outside of the current mineral resource area at La Preciosa, subject to a cap of US$50 million, with any such payments to be credited against any existing or future payments owing on the gross value returns royalty.

Background to the Transaction

The La Preciosa Obligations were initially issued to Coeur Mining, Inc. (“Coeur“) in connection with the acquisition of La Preciosa by Avino in March 2022. Details of the Company’s acquisition of La Preciosa are available on the Company’s website here. Following the acquisition, Coeur sold the La Preciosa Obligations to Trident Royalties Plc (“Trident“) in May 2023, with Deterra subsequently acquiring the La Preciosa Obligations by way of its acquisition of Trident in September 2024.

Transaction Consideration

Avino acquired the La Preciosa Obligations from Deterra for immediate cash consideration of US$13.25 million (the “Upfront Payment“), plus an additional US$8.75 million in cash payable on the one-year anniversary of the closing of the Transaction (the “Deferred Payment“). The Upfront Payment was funded with Avino’s existing cash on hand, which was approximately US$48 million, immediately prior to this acquisition. The Deferred Payment was structured to substantially mirror the pre-existing Contingent Production Payment which Avino expects to pay by the end of 2026, given that initial production at La Preciosa is targeted in late 2025. As such, Avino believes the net cash investment for the purchase and extinguishment of the La Preciosa Obligations to be the Upfront Payment, with the Contingent Production Payment already considered in the Company’s capital allocation for the coming years. The Deferred Payment is expected to be funded with cash on hand.

Transaction Rationale

Avino has made excellent progress advancing La Preciosa with first production expected by the end of 2025 and significant production growth expected in the years thereafter which will see La Preciosa become a cornerstone asset for the Company. La Preciosa is one of the largest undeveloped silver resources in Mexico (see current NI 43-101 Resource Estimate below)located adjacent to Avino’s existing mine and infrastructure. Eliminating the 1.25% net smelter returns royalty on the Gloria and Abunduncia veins and the 2.00% gross value returns royalty on the remainder of the La Preciosa resource will meaningfully lower La Preciosa’s cash production costs, as well as remove any future potential obligations if new reserves are discovered outside of the current resource area.

Notes:

The stated mineral resources are classified in accordance with the Canadian Institute of Mining, Metallurgy and Petroleum’s “CIM Definition Standards – For Mineral Resources and Mineral Reserves” and are more particularly described in the Company’s February 5, 2024 Prefeasiblity Study, available under the Company’s profile at www.sedarplus.ca.

Mineral resources for La Preciosa are estimated at a cut-off grade of 120 g/t AgEq.

Mineral resources for La Preciosa are estimated using a long-term silver price of US$19.00/oz and a long-term gold price of US$1,750/oz.

Mineral resources are not mineral reserves and do not have demonstrated economic viability.

Tonnage and metal content figures are expressed in thousands and may not add up due to rounding.

La Preciosa Development Update

As seen in our latest press release dated July 22, 2025, blasting and construction of the relatively short 360 meter San Fernando main access decline is underway, and equipment mobilization has been swift, allowing development to advance on plan. The new jumbo drill is working on this ramp as it progresses toward intercepting the Gloria and Abundancia veins. Recent photos showcasing the work at La Preciosa are available on the Avino website – click here to view them.

A surface drill has been deployed to La Preciosa and drilling is expected to continue until the end of October. The drilling information will be utilized in underground mine planning and 3D modelling. The Company is also planning to update the current mineral resource estimate for Avino and La Preciosa was well as releasing its first mineral reserve estimate at the same time as the Company has now met the requirements for a Producing Issuer under the NI 43-101 standards of disclosure for mineral projects.

A more comprehensive drilling update will be released in the coming weeks.

Qualified Person(s)

Peter Latta, P.Eng., MBA, Avino’s VP Technical Services, is a qualified person within the context of National Instrument 43-101, has reviewed and approved the technical data in this news release.

About Avino

Avino is a silver producer from its wholly owned Avino Mine near Durango, Mexico. The Company’s silver, gold and copper production remains unhedged. The Company intends to maintain long term sustainable and profitable mining operations to reward shareholders and the community alike through our growth at the historic Avino Property and the strategic acquisition of the adjacent La Preciosa which was finalized in Q1 2022. Avino has a large silver equivalent resource base with consolidated mineral resources of 277 million AgEq ounces in the measured and indicated mineral resource category and 94 million AgEq ounces in the inferred mineral resource category. Early in 2024, the pre-feasibility Study on the Oxide Tailings Project was completed. This study represents a key milestone in our growth trajectory. As part of Avino’s commitment to adopting sustainable practices, we have been operating a dry-stack tailings facility for more than two years with excellent results. We are committed to managing all business activities in a safe, environmentally responsible, and cost-effective manner, while contributing to the well-being of the communities in which we operate. We encourage you to connect with us on X (formerly Twitter) at @Avino_ASM and on LinkedIn at Avino Silver & Gold Mines. To view the Avino Mine VRIFY tour, please click here.

For Further Information, Please Contact:

Investor Relations
Tel: 604-682-3701
Email: IR@avino.com

This news release contains “forward-looking information” and “forward-looking statements” (together, the “forward looking statements”) within the meaning of applicable securities laws and the United States Private Securities Litigation Reform Act of 1995. This information and these statements, referred to herein as “forward-looking statements” are made as of the date of this document. Forward-looking statements relate to future events or future performance and reflect current estimates, predictions, expectations or beliefs regarding future events and include, but are not limited to, statements with respect to the Company’s payment of US$8.75 million in cash to Deterra within 12 months from Closing. Any statements that express or involve discussions with respect to predictions, expectations, beliefs, plans, projections, objectives or future events or performance (often, but not always, using words or phrases such as “expects”, “anticipates”, “plans”, “projects”, “estimates”, “envisages”, “assumes”, “intends”, “strategy”, “goals”, “objectives” or variations thereof or stating that certain actions, events or results “may”, “could”, “would”, “might” or “will” be taken, occur or be achieved, or the negative of any of these terms and similar expressions) are not statements of historical fact and may be forward-looking statements. These forward-looking statements are made as of the date of this news release. Readers are cautioned not to place undue reliance on forward-looking statements, as there can be no assurance that the future circumstances, outcomes or results anticipated in or implied by such forward-looking statements will occur or that plans, intentions or expectations upon which the forward-looking statements are based will occur. While we have based these forward-looking statements on our expectations about future events at the date that such statements were prepared, the statements are not a guarantee that such future events will occur and are subject to risks, uncertainties, assumptions and other factors which could cause events or outcomes to differ materially from those expressed or implied by such forward-looking statements.

Cautionary note to U.S. Investors concerning estimates of Mineral Reserves and Mineral Resources

All reserve and resource estimates reported by Avino were estimated in accordance with the Canadian National Instrument 43-101 and the Canadian Institute of Mining, Metallurgy and Petroleum (“CIM”) Definition Standards. The U.S. Securities and Exchange Commission (“SEC”) now recognizes estimates of “measured mineral resources,” “indicated mineral resources” and “inferred mineral resources” and uses new definitions of “proven mineral reserves” and “probable mineral reserves” that are substantially similar to the corresponding CIM Definition Standards. However, the CIM Definition Standards differ from the requirements applicable to US domestic issuers. US investors are cautioned not to assume that any “measured mineral resources,” “indicated mineral resources,” or “inferred mineral resources” that the Issuer reports are or will be economically or legally mineable. Further, “inferred mineral resources” are that part of a mineral resource for which quantity and grade are estimated on the basis of limited geologic evidence and sampling. Mineral resources which are not mineral reserves do not have demonstrated economic viability.

Neither TSX nor its Regulation Services Provider (as that term is defined in the policies of the TSX) accepts responsibility for the adequacy or accuracy of this release.

SOURCE: Avino Silver & Gold Mines Ltd.

View the original press release on ACCESS Newswire

Vision Marine Technologies (NASDAQ:VMAR) expands E-Motion(TM) to 25 vessels, lake, and sport platforms, reinforcing a strong growth trajectory through its 9 Nautical Ventures dealerships.

MONTREAL QC / ACCESS Newswire / August 25, 2025 / Vision Marine Technologies Inc. (NASDAQ:VMAR) (“Vision Marine” or the “Company”), a pioneer in high-voltage marine propulsion and multi-brand boat retail, today reaffirmed that its E-Motion™ remains the fastest electric boat technology in the world. Nearly two years after setting the 116-mph electric speed record at the Lake of the Ozarks Shootout in collaboration with Shaun Torrente Racing, the benchmark stands unmatched-underscoring the Company’s enduring edge in marine electrification.

Since achieving this milestone, Vision Marine has advanced the E-Motion™ 180E from record-breaking demonstration to commercial reality. The system-an industrialized 180-horsepower high-voltage outboard engineered specifically for marine use-has now been integrated into 25 boats across multiple recreational platforms, including pontoons, bowriders, dual consoles, center consoles, and catamarans.

Watch the 2023 documentary: Can’t Stop, Won’t Stop YouTube Amazon Prime

Through its Nautical Ventures division-one of the most prominent dealer networks in Florida, the world’s boating capital-Vision Marine is uniquely positioned to bring this technology to market. Nautical Ventures’ nine retail locations, marina operations, and customer database exceeding 50,000 provide the infrastructure to deliver E-Motion™ directly to boaters. With more than $100 million in annual boat sales over recent years, Nautical Ventures strengthens the bridge from Vision Marine’s proven technology to consumer adoption.

“We’re in a bold new development and training phase, and Vision Marine is becoming the reference in America for electric boating. We are also proud of the University of Michigan for its efforts, which highlight the importance of the next generation in advancing this transition. Our focus is now on the growth and profitability of our nine-dealership network, with staff training to deliver the E-Motion™ outboard and strengthen the ecosystem that brings this technology to customers,” said Alexandre Mongeon, CEO and Co-Founder. “When we broke the record, we proved that electric boating can compete at the highest levels of performance. Today, that same technology is validated and available to customers through Florida’s strongest dealer platform. We remain faster than 80% of ICE boats at the Ozarks, underscoring our enduring performance edge, while building a sustainable foundation that creates lasting value for investors. Once the record is challenged, we will return with determination to push the boundaries even further.”

While the Company has not actively competed this year, its focus has been on strengthening its distribution network to accelerate the rollout of its E-Motion™ electric propulsion, while at the same time driving growth through continued ICE boat sales-building a stronger, more balanced platform for long-term value creation.

With unmatched performance, a growing portfolio of OEM integrations, and the capacity to deliver and service boats at scale, Vision Marine continues to expand access to the E-Motion™ 180E across recreational and commercial marine markets.

About Vision Marine Technologies Inc.
Vision Marine Technologies Inc. (NASDAQ:VMAR) is a pioneer in marine innovation, offering premium boating experiences across both electric and internal combustion engine (ICE) segments. The Company designs, manufactures, and sells its flagship E-Motion™ 180E high-voltage electric outboard system-an industrialized, high-performance solution validated through multiple OEM integrations-while also providing consumers with access to a full range of boats through its Nautical Ventures division. With nine retail locations in Florida, annual boat sales exceeding $100 million, and established service and marina operations, Vision Marine delivers market-ready solutions to meet the current and evolving needs of recreational boaters and commercial operators.

For more information, please visit www.visionmarinetechnologies.com.

Forward-Looking Statements
This press release contains forward-looking statements within the meaning of applicable securities laws. These statements are based on current expectations and assumptions and are subject to risks and uncertainties that may cause actual results to differ materially. Factors that could cause such differences include, but are not limited to, market adoption, regulatory developments, competition, and operational execution. Vision Marine disclaims any obligation to update these statements, except as required by law.

Investor and Company Contact:

Bruce Nurse
Investor Relations
(303) 919‑2913
bn@v‑mti.com

SOURCE: Vision Marine Technologies Inc

View the original press release on ACCESS Newswire

With flexible lending solutions and a dedication to financial inclusion, Liberty is supporting women to take the leap into property investment.

MELBOURNE, AU / ACCESS Newswire / August 25, 2025 / Recent CoreLogic data shows that just 11.4% of Australian women own at least one investment property which is about 20% lower when compared to men.

While these figures reveal a gender gap, they also point to growing parity in overall property ownership, suggesting more women are stepping into the market with confidence.

Whether it’s a first investment or a growing portfolio, non-bank lender Liberty offers tailored solutions to help a range of borrowers achieve their property goals.

According to Communications Manager Bernadine Pantarotto, Liberty’s flexible home loans are designed to support more people with greater choice.

“We take the time to understand each borrower, because no two journeys to home ownership or property investment are the same,” explained Ms. Pantarotto.

Liberty’s inclusive lending approach also welcomes borrowers with variable income or imperfect credit history.

“We’re proud to support women with free thinking lending solutions as they navigate their financial journey,” said Ms. Pantarotto.

This flexibility could be especially valuable for women managing career breaks, or family responsibilities.

“Our home loan options are designed to support borrowers throughout life’s big moments – from a new investment goal to a career change or growing family,” said Ms. Pantarotto.

With features including offset accounts, interest-only terms, redraw facilities, and higher LVRs, Liberty home loan solutions are tailored to suit borrowers’ goals and unique circumstances.

“Many of our customers are self-employed or have non-traditional income streams, and we’re proud to offer solutions that reflect real life,” said Ms. Pantarotto.

Whether borrowers are purchasing their first home, refinancing, or expanding a property portfolio, Liberty can help.

“Our range of home loan solutions, including low doc and low deposit home loans, could help more borrowers accelerate their property plans,” said Ms. Pantarotto.

Liberty’s lending options can also support other life goals, from renovating a home, to launching a business or planning a well-earned getaway.

About Liberty
As one of Australia’s leading non-bank lenders, Liberty offers innovative solutions to support customers with greater choice. For nearly 30 years, this free-thinking approach to loan solutions has seen more than 900,000 customers across a wide range of home, car, business and personal loans, as well as SMSF lending and insurance. Liberty remains the only non-bank lender with an investment-grade credit rating offering custom and prime solutions to help more people get financial.

Approved applicants only. Lending criteria apply. Fees and charges are payable. Liberty Financial Pty Ltd ACN 077 248 983 and Secure Funding Pty Ltd ABN 25 081 982 872 Australian Credit Licence 388133, together trading as Liberty Financial.

Contact
Laura Orchard
Media Coordinator
P: +61 3 8635 8888
E: mediaenquiries@liberty.com.au

SOURCE: Liberty

View the original press release on ACCESS Newswire

Structural investigation to guide future exploration targeting

HIGHLIGHTS

• March 2025 Tolmer discovery hole ranked 5th highest-grade silver intersection reported globally during H1 2025, with an interval of 6m @ 4,747 g/t Ag from only 46m depth¹

• New assays have extended high grade silver horizons, and added coincident high-grade gold up to ~13g/t Au, within a highly mineralised footprint now ~1.5km wide²

ADELAIDE, AUSTRALIA / ACCESS Newswire / August 24, 2025 / Barton Gold Holdings Limited (ASX:BGD)(FRA:BGD3)(OTCQB:BGDFF) (Barton or Company) is pleased to confirm the completion of diamond drilling (DD) at the high-grade Tolmer gold and silver prospect, located at the Company’s South Australian Tarcoola Gold Project (Tarcoola). Three holes totalling 595.3 metres drilling were completed in the ‘eastern gold zone’ to identify structural controls and guide future targeting.

Commenting on the Tolmer diamond drilling, Barton Managing Director Alexander Scanlon said:

“Tolmer is an exciting new discovery near our Central Gawler Mill, with shallow gold and silver up to 83.6g/t Au and 17,600g/t Ag. This initial round of diamond drilling will give us a helpful ‘first look’ at local structural controls and, together with the pending results of soil assays over the whole area, will help guide future targeting across a now 1.5km wide footprint of shallow, high-grade mineralisation. We look forward to sharing further updates.”

¹According to Rock Report analysis available here and at https://rockreportnews.com/graphics/; refer to ASX announcement dated 27 March 2025
²Refer to ASX announcement dated 5 August 2025

Program background

During August 2024 Barton announced a Tolmer high-grade gold discovery and then, during March 2025, Barton announced one of Australia’s highest-grade modern silver discoveries ~500m further west.³ These neighbouring ‘eastern gold zone’ and ‘western silver zone’ discoveries have yielded grades up to 83.6g/t Au and 17,600g/t Ag, respectively, with high-grade gold and silver present in each zone.³

Recent RC drilling assays extended broad silver mineralisation and also added high-grade gold to the ‘western silver zone’ (see Table 1), yielding a highly enriched mineralised footprint ~1.5km wide.⁴ While silver up to 117g/t Ag was encountered in fresh rock in this drilling, the origin of this high-grade mineralisation has not yet been confirmed, and is a key focus of ongoing investigation.

Table 1 – Key new high-grade gold and silver assays in ‘western silver zone’ of Tolmer prospect⁴

³Refer to ASX announcements dated 27 August 2024, and 30 January, 27 March, 16 April and 5 August 2025
⁴Refer to ASX announcement dated 5 August 2025

Multiple horizons of broad, shallow high-grade Au-Ag mineralisation

Recent RC drilling in Tolmer’s ‘western silver zone’ have infilled and extended an ‘upper horizon’ of shallow, broad ‘silver dominant’ mineralisation (largely independent of gold) to the west, while adding additional high-grade gold and silver intervals to a much higher-grade ‘lower horizon’ with silver up to 17,600g/t Ag.⁵

Recent drilling also identified a potential southern extension of the ‘lower horizon’ containing both high grade gold and silver (see Figure 4), as well as silver intersections up to 117g/t Ag in the underlying fresh rock.⁵ The goal of new diamond drilling is to identify local structural controls to guide future drill targeting.

⁵Refer to ASX announcement dated 5 August 2025

Soil sampling program also underway

In July 2025 Barton completed a soil sampling program over a ~1.9km² area surrounding the ‘Tolmer’ high grade silver and gold discoveries, collecting ~430 samples with assays expected during September 2025.⁶

⁶Refer to ASX announcement dated 14 July 2025

Authorised by the Managing Director of Barton Gold Holdings Limited.

For further information, please contact:

About Barton Gold
Barton Gold is an ASX, OTCQB and Frankfurt Stock Exchange listed Australian gold developer targeting future gold production of 150,000ozpa with 2.1Moz Au & 3.1Moz Ag JORC Mineral Resources (78.9Mt @ 0.85 g/t Au), brownfield mines, and 100% ownership of the region’s only gold mill in the renowned Gawler Craton of South Australia.*

*Refer to Barton Prospectus dated 14 May 2021 and ASX announcement dated 25 July 2025. Total Barton JORC (2012) Mineral Resources include 1,049koz Au (39.7Mt @ 0.82 g/t Au) in Indicated category and 1,095koz Au (39.2Mt @ 0.87 g/t Au) in Inferred category, and 3,070koz Ag (34.5Mt @ 2.80 g/t Ag) in Inferred category as a subset of Tunkillia gold JORC (2012) Mineral Resources.

Challenger Gold Project 223koz Au + fully permitted Central Gawler Mill (CGM) Tarcoola Gold Project 20koz Au in fully permitted open pit mine near CGM Tolmer discovery grades up to 84g/t Au & 17,600g/t Ag Tunkillia Gold Project 1.6Moz Au & 3.1Moz Ag JORC Mineral Resources Competitive 120kozpa gold & 250kozpa silver project Wudinna Gold Project 279koz Au project located southeast of Tunkillia Significant optionality, adjacent to main highway

Competent Persons Statement & Previously Reported Information

The information in this announcement that relates to the historic Exploration Results and Mineral Resources as listed in the table below is based on, and fairly represents, information and supporting documentation prepared by the Competent Person whose name appears in the same row, who is an employee of or independent consultant to the Company and is a Member or Fellow of the Australasian Institute of Mining and Metallurgy (AusIMM), Australian Institute of Geoscientists (AIG) or a Recognised Professional Organisation (RPO). Each person named in the table below has sufficient experience which is relevant to the style of mineralisation and types of deposits under consideration and to the activity which he has undertaken to quality as a Competent Person as defined in the JORC Code 2012 (JORC).

Activity	Competent Person	Membership	Status
Tarcoola Mineral Resource (Stockpiles)	Dr Andrew Fowler (Consultant)	AusIMM	Member
Tarcoola Mineral Resource (Perseverance Mine)	Mr Ian Taylor (Consultant)	AusIMM	Fellow
Tarcoola Exploration Results (until 15 Nov 2021)	Mr Colin Skidmore (Consultant)	AIG	Member
Tarcoola Exploration Results (after 15 Nov 2021)	Mr Marc Twining (Employee)	AusIMM	Member
Tunkillia Exploration Results (until 15 Nov 2021)	Mr Colin Skidmore (Consultant)	AIG	Member
Tunkillia Exploration Results (after 15 Nov 2021)	Mr Marc Twining (Employee)	AusIMM	Member
Tunkillia Mineral Resource	Mr Ian Taylor (Consultant)	AusIMM	Fellow
Challenger Mineral Resource	Mr Ian Taylor (Consultant)	AusIMM	Fellow
Wudinna Mineral Resource (Clarke Deposit)	Ms Justine Tracey	AusIMM	Member
Wudinna Mineral Resource (all other Deposits)	Mrs Christine Standing	AusIMM / AIG	Member / Member

The information relating to historic Exploration Results and Mineral Resources in this announcement is extracted from the Company’s Prospectus dated 14 May 2021 or as otherwise noted in this announcement, available from the Company’s website at www.bartongold.com.au or on the ASX website www.asx.com.au. The Company confirms that it is not aware of any new information or data that materially affects the Exploration Results and Mineral Resource information included in previous announcements and, in the case of estimates of Mineral Resources, that all material assumptions and technical parameters underpinning the estimates, and any production targets and forecast financial information derived from the production targets, continue to apply and have not materially changed. The Company confirms that the form and context in which the applicable Competent Persons’ findings are presented have not been materially modified from the previous announcements.

Cautionary Statement Regarding Forward-Looking Information

This document may contain forward-looking statements. Forward-looking statements are often, but not always, identified by the use of words such as “seek”, “anticipate”, “believe”, “plan”, “expect”, “target” and “intend” and statements than an event or result “may”, “will”, “should”, “would”, “could”, or “might” occur or be achieved and other similar expressions. Forward-looking information is subject to business, legal and economic risks and uncertainties and other factors that could cause actual results to differ materially from those contained in forward-looking statements. Such factors include, among other things, risks relating to property interests, the global economic climate, commodity prices, sovereign and legal risks, and environmental risks. Forward-looking statements are based upon estimates and opinions at the date the statements are made. Barton undertakes no obligation to update these forward-looking statements for events or circumstances that occur subsequent to such dates or to update or keep current any of the information contained herein. Any estimates or projections as to events that may occur in the future (including projections of revenue, expense, net income and performance) are based upon the best judgment of Barton from information available as of the date of this document. There is no guarantee that any of these estimates or projections will be achieved. Actual results will vary from the projections and such variations may be material. Nothing contained herein is, or shall be relied upon as, a promise or representation as to the past or future. Any reliance placed by the reader on this document, or on any forward-looking statement contained in or referred to in this document will be solely at the readers own risk, and readers are cautioned not to place undue reliance on forward-looking statements due to the inherent uncertainty thereof.

SOURCE: Barton Gold Holdings Limited

View the original press release on ACCESS Newswire

BARCELONA, ES / ACCESS Newswire / August 24, 2025 / The Tripathi Foundation Inc. today announced the release of a groundbreaking draft manuscript entitled The Tree of Unified Reality. The work presents a layered framework that seeks to unify physics, mathematics, and information into a single structured model.

The manuscript organizes reality as a living Tree:

Roots (Being & Existence): the foundations of ontology, the fact that something exists.

Trunk (Information & Law): the invariants, symmetries, and entropic bounds that give rise to stability and order.

Branches (Frameworks): spacetime, matter, forces, and symmetries, expressed as coherent but diverse structures.

Leaves (Observables): the experimental data and measurements that connect theory with reality.

Fruits (Predictions): testable, falsifiable consequences across cosmology, gravity, particle physics, and quantum information.

“This is not the end of discovery – it is a new beginning. The Tree framework doesn’t just unify laws, it explains why unification itself is a natural process. It respects history, incorporates mathematics, and points toward new experiments. It is both rigorous and alive.”

A Framework That Is Mathematically Consistent

Unlike many speculative unification attempts, the Tree of Unified Reality is mathematically consistent at every layer.

Stability functionals are rigorously defined using measure theory and dynamical systems.

Branches are modeled as functors in category theory, ensuring invariants are preserved across physical domains.

Observables form closed operator algebras, aligning with classical and quantum frameworks.

Conservation laws follow directly from informational invariance, extending Noether’s principle.

This guarantees that the Tree is not just metaphor, but a formally grounded, internally coherent model ready for peer review and empirical testing.

Why This Matters

Scientific Impact: offers bounded, falsifiable predictions that can be tested in cosmology, gravitational waves, colliders, and quantum labs.

Philosophical Depth: connects Being, Existence, and Information to modern science in a rigorous way.

Historical Continuity: reframes past unifications as growth of the same Tree, not isolated revolutions.

Vision: suggests that science itself is a living structure – perpetual, fertile, and open-ended.

Next Steps

This work is presented as a theory – a draft framework meant for open scientific review and dialogue. The Tripathi Foundation will be circulating the manuscript to physicists, mathematicians, and philosophers worldwide. It is intended as a testable, peer-reviewable proposal, not as a closed or final declaration.

Closing Reflection

The Tree of Unified Reality is not the “end of the quest for information,” but a renewal of it. By rooting science in Being and Information, and by organizing knowledge as a living Tree, the framework invites humanity to see unification not as a final formula but as an ongoing growth of understanding.

If confirmed, the Tree of Unified Reality could mark not just a turning point in physics, but the beginning of a new era of understanding – where humanity sees itself as part of a living, ordered cosmos, and uses that knowledge to guide science, culture, and the future of mankind.

SOURCE: Tripathi Foundation Inc

View the original press release on ACCESS Newswire

With contributions by Dr. G. N. R. Tripathi

NOTRE DAME, IN / ACCESS Newswire / August 23, 2025 / For the first time, researchers have presented a unified mathematical formulation that compactly brings together the known fundamental interactions of nature.

The Equation of Forces (EoF) condenses gravity, electromagnetism, and the weak and strong nuclear forces into a single coherent structure. This unification is achieved not by extra spatial dimensions or speculative constructs, but within a four-dimensional, renormalization-group consistent framework, allowing predictive connections across energy scales.

Building on this foundation, the Equation of Everything (EoE) extends the principle: it integrates not only the four forces but also cosmological dynamics, quantum structure, and information flow into a single overarching framework. This represents a step beyond force unification – toward a description of physical law that spans quarks to cosmos, entropy to spacetime.

Why This Matters

For over a century, unification has been the “holy grail” of theoretical physics. Newton revealed one law for apples and planets. Maxwell bound electricity and magnetism. Einstein unified space and time, matter and geometry. Now, for the first time, all four forces are written in one equation that remains mathematically consistent up to the Planck scale.

Unlike previous approaches such as string theory or loop quantum gravity, this framework:

Requires no extra dimensions.

Reduces free parameters, with masses and mixing angles predicted from a single organizing principle.

Bridges micro and macro, showing how the same flow governs proton decay rates, neutrino oscillations, dark matter relics, and inflationary dynamics.

Potential Impact

If borne out, the EoF and EoE could:

Unlock deep puzzles: shedding light on black holes, dark energy, and the arrow of time.

Redefine the role of information: treating entropy and quantum coherence as fundamental ingredients of physics, not emergent byproducts.

Guide next-generation experiments: predicting linked signals – proton decay, neutrino parameters, inflationary spectra – where one test can confirm or falsify the entire framework.

Inspire new technologies: from quantum computing architectures grounded in unified principles, to energy models informed by higher-order curvature terms.

A Call to Action

This is not a final Theory of Everything. It is a framework – an organizing script that appears mathematically self-consistent and testable. Its fate will depend on the scrutiny of the global scientific community.

If validated, this achievement would stand beside Newton, Maxwell, and Einstein – as a new pillar in humanity’s quest to understand reality.

Disclaimer: This perspective is provided for informational purposes only. It is not presented as, and does not purport to be, a proven truth. It is a structured lens for inquiry, subject to the full scrutiny of the scientific method. While efforts have been made to ensure accuracy and completion, the author(s) make no guarantees and accept no liability whatsoever for any errors, omissions, or outcomes arising from the contents herein and/or its use, and expressly disclaim any such liability. This work does not constitute medical, legal, accounting or other professional advice.s

SOURCE: Tripathi Foundation Inc

View the original press release on ACCESS Newswire